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Conrad Murray appeared before Judge Keith Schwartz and entered a not guilty plea after turning himself in at a branch courthouse near Los Angeles International Airport, CNN reported.

Bail was set at $75,000, the Los Angeles Times said.

Michael Jackson's parents, Joe and Katherine, and three of his brothers, were at the courthouse when Murray arrived. CNN reported that when he was asked for his reaction to the charge of involuntary manslaughter, brother Jermaine Jackson said, "Not enough."

Murray had been under investigation for his treatment of Jackson in the time leading to the singer's death at age 50 with lethal levels of the anesthesia propofol and sedatives in his system.

Police have said Murray, based in Texas, admitted he administered the drugs to Jackson to help him sleep shortly before he died June 25.

The Superior Court complaint against Murray claims he "did unlawfully, and without malice, kill Michael Joseph Jackson" by acting "without due caution and circumspection", reports said.

Murray has repeatedly denied any wrongdoing and his lawyer has said he fully cooperated with the investigation.

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