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SMA Screening Not Cost Effective For All
Friday, 05-Feb-2010 12:54PM United Press International
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BOSTON, Feb. 5 (UPI) -- Prenatal screening for spinal muscular atrophy may only be cost effective for women with a family history of the disease, a Massachusetts doctor said.

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Spinal muscular atrophy, SMA, is the most common genetic cause of infant mortality.

Screenings cost about $400 each and 11,000 women would have to be screened to prevent one case of SMA, said Dr. Sarah Little of Massachusetts General Hospital. Little and her colleagues were to present their findings Friday at a Society for Maternal-Fetal Medicine meeting in Chicago.

"Our findings show that screening everyone for SMA is not cost effective", Little said in a release Thursday. "Our results, however, were most sensitive to changes in the baseline prevalence of disease, suggesting that prenatal SMA screening may be cost effective in high risk populations, such as those with a family history of disease."

In 2008, the American College of Medical Genetics recommended screening should be made available to all pregnant women, while the American College of Obstetricians and Gynecologists last year recommended against screening in the general population.

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