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Viral Recombination Of HIV Fools Immunity
Tuesday, 22-Jul-2008 11:54PM United Press International
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BOSTON, July 22 (UPI) -- How and where viral strains of HIV swap DNA may be determined by the immune response against the original infecting strain, U.S. researchers said.

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Researchers at the partners AIDS Research Center at Massachusetts General Hospital said that when individuals infected with HIV become infected with a second strain of the virus, the two viral strains can exchange genetic information, creating a third, recombinant strain of the virus.

These multiple viral strains, called superinfection, frequently lead to a loss of immune control of viral levels.

"The implication that recombination events are selected by immune responses identifies a new mechanism for the virus to escape the patient's immune system, which would present additional challenges to vaccine design", one of the study's lead authors, Dr. Hendrik Streeck, said in a statement.

"This finding also has worldwide implications for the development of more complex strains of HIV."

The study is published online in the Journal of Experimental Medicine.

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