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Dr. R. Michael Stiatkowski of the Dean McGee Eye Institute/University of Oklahoma and colleagues evaluated the effects of pirenzepine in children with myopia -- a condition in which focus on near objects is good, but distant objects appear blurry.

Caused by a problem with the length of the eyeball or the curvature of the cornea, myopia gets worse over time in many children, Stiatkowski said.

In the study, children with myopia were randomly assigned to treatment with pirenzepine gel or an inactive placebo gel. After a year of treatment, the average increase in myopia was significantly less for children using pirenzepine. Eighty-four patients continued treatment for a total of two years: 53 with pirenzepine and 31 with placebo.

The study, published in the Journal of American Association for Pediatric Ophthalmology and Strabismus, found that although myopia worsened in both groups of children, the rate of progression was slower with pirenzepine.

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