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CNN and MSNBC reported the New York senator was expected to beat out her colleague from Illinois by a 2-1 margin, according to exit polls.

With 2 percent of the vote counted, Clinton led Obama 63 percent to 30 percent, CNN reported.

Meanwhile, Obama has turned his attention to Missouri, a key general election swing state, rather than staying in West Virginia.

The results of the West Virginia primary, however, will have little impact on the race for Democratic delegates, in which Obama has piled up an all-but-insurmountable lead.

Instead, Obama is focusing his strategy on the general election and the presumptive Republican nominee, Sen. John McCain, R-Ariz., by turning his attention to Missouri, which has already held its Democratic primary. He was set to have a town hall meeting in Cape Girardeau, Mo.

Despite her likely resounding win in West Virginia, Clinton's challenge continues to fade. In addition to trailing Obama in pledged delegates, a CNN count showed Obama leading among superdelegates. Her campaign has also revealed it is $20 million in the red.

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